| 摘要: |
| 贝类对全球渔业发展和人类生计至关重要，其产量约占世界海水养殖产量的56%。雌雄同体型Argopecten属海湾扇贝（Argopecten irradians irradians）和紫扇贝（Argopecten purpuratus）是具有高营养价值和经济价值的贝类，二者的种间杂交后代表现出极显著的生长优势，具有巨大的育种潜力。然而，两者的绝大多数杂交后代都表现为不育，限制了杂交育种技术的进一步开发和规模化应用。本文从遗传和环境角度综述了两种Argopecten属扇贝种间杂交不育的潜在机制。线粒体基因和核基因突变、异常核质相互作用、表观遗传修饰失调以及环境因子温度变化引起的能量供应不足、有丝分裂和减数分裂缺陷、高水平的细胞凋亡和活性氧水平以及配子的发生和成熟受阻可能是导致Argopecten属扇贝种间杂交不育的关键原因。此外，EGFR基因也在杂交贝的育性调控中发挥着重要的作用。本综述为揭示扇贝种间杂交不育的决定机制提供了新的策略和方向，并为贝类的规模化杂交育种奠定了理论基础，有望为相关研究提供参考以促进水产养殖业的健康发展。 |
| 关键词: 杂交不育 雌雄同体 Argopecten属扇贝 细胞凋亡 能量缺陷 减数分裂 |
| DOI： |
| 分类号:P735 |
| 基金项目:国家自然科学基金项目（31972791，42276147）；山东省重点研发计划项目（2023ZGCQY006）；山东省贝类产业技术体系遗传育种岗位专家（SDAIT-14） |
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| Determination mechanisms of interspecific hybrid sterility in Argopecten scallops |
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Yu Tieying1, Ning Junhao1, Lu Xia2, Wang Chunde1
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1.Yantai Institute of Coastal Zone Research,Chinese Academy of Sciences;2.Yantai University
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| Abstract: |
| Molluscs are vital to global fisheries and human livelihoods, accounting for about 56% of the world's mariculture production. The hermaphroditic bay scallops (Argopecten irradians irradians) and Peruvian scallops (Argopecten purpuratus) are shellfish with high nutritional and economic value. The interspecific hybrids between the two species exhibited remarkable advantages in growth and had great potential in Argopecten scallop breeding. Nevertheless, the fact that most interspecific hybrids are infertile limits the further development and large-scale application of scallop crossbreeding technology. This review summarizes the potential mechanisms of hybrid sterility between the two Argopecten scallops from genetic and environmental perspectives. Insufficient energy supply, dysregulation of mitosis and meiosis, high levels of apoptosis and ROS, obstruction of gametogenesis and maturation caused by mutations in mitochondrial and nuclear genes, aberrant nucleocytoplasmic interactions, defective epigenetic modifications, and changes in the temperature of environmental factors may be the most critical reasons for interspecific hybrid sterility in Argopecten scallops. Besides, the EGFR gene may also play a key role in the fertility regulation of hybrid scallops. This review may provide new insights into understanding the determination mechanisms of interspecific hybrid sterility in scallops and lay a theoretical foundation for large-scale hybrid breeding of shellfish. It is expected to provide references for related research to promote the healthy development of aquaculture industry. |
| Key words: hybrid sterility hermaphroditic Argopecten scallops apoptosis energy deficiency meiosis |