| 摘要: |
| 海洋双壳贝类在全球渔业与水产养殖中具有显著的经济和生态价值。美国学者曾提出海洋双壳贝类是研究自然老化与长寿调控机制的理想模型。Argopecten属海湾扇贝(A. irradians)(<14个月)和紫扇贝(A. purpuratus)(7-10年)不完全生殖隔离,但在长期适应不同环境的进化过程中,各自基因组的遗传变异导致了二者不同的寿命周期,为研究寿命演化机制提供了独特材料。IIS通路(胰岛素/胰岛素样生长因子信号通路)是机体从生长、代谢到生殖和寿命等生命过程的关键信号传导途径,是第一个被发现且得到广泛验证的衰老调控信号通路。本文从遗传和环境角度综述了IIS通路在两种Argopecten属扇贝寿命决定中的潜在机制。遗传变异导致IIS通路核心基因不同的蛋白酶活性及磷酸化水平,环境胁迫下IIS通路调控、抗氧化和DNA修复、代谢调节等方面的差异可能是导致Argopecten属扇贝寿命差异的重要原因。本综述为海洋双壳贝类寿命演化机制的研究提供了新思路,进一步提升对衰老和长寿机制理论的新认知。同时,也为选育长寿命、大规格扇贝提供了理论依据和生物标志物。 |
| 关键词: Argopecten属扇贝 寿命 IIS通路 营养限制 电离辐射 基因组稳定 |
| DOI： |
| 分类号:P735 |
| 基金项目:国家自然科学(42276147,31972791)；山东省重点研发计划项目(2023ZGCQY006)；山东省贝类产业技术体系遗传育种岗位专家(SDAIT-14)。 |
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| The Regulatory Mechanism of Lifespan in Bay Scallops and Peruvian Scallops of the Argopecten |
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Zhang Zebin1, Jiang Nan1, Tang Yongzheng1, Wang Chunde2, Lu Xia1
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1.Yantai University,Yantai;2.Yantai Institute of Coastal Zone Research,Chinese Academy of Sciences,Yantai
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| Abstract: |
| Marine bivalves hold significant economic, ecological, and sustainable development value in global fisheries and aquaculture. American scholars have suggested that marine bivalves are ideal models for studying the regulatory mechanisms of natural ageing and longevity. Bay scallops (Argopecten irradians) (less than 14 months) and Peruvian scallops (A. purpuratus) (7-10 years) are not completely reproductively isolated; however, the genetic variations in their genomes resulting from long-term adaptation to different environments have led to distinct lifespans, providing unique materials for investigating lifespan evolution mechanisms. The IIS pathway (insulin/insulin-like growth factor signalling pathway) is a key signalling pathway in various life processes, including growth, metabolism, reproduction, and lifespan. It is the first ageing regulatory signalling pathway discovered and widely validated. This article reviews the potential mechanisms by which the IIS pathway influences lifespan determination in the two species of Argopecten from genetic and environmental perspectives. Genetic variation results in differences in protease activity and phosphorylation levels of core genes within the IIS pathway. Under environmental stress, variations in IIS pathway regulation, antioxidant and DNA repair responses, and metabolic regulation may contribute to the lifespan differences observed among Argopecten scallops. This review provides new insights into studying lifespan evolution mechanisms in marine bivalves, further enhancing the theoretical understanding of ageing and longevity mechanisms. Additionally, it offers theoretical foundations and biological markers for breeding long-lived, larger-sized scallops. |
| Key words: Argopecten scallops lifespan IIS pathway nutritional restriction ionizing radiation genomic stability |