| 摘要: |
| 依据80—90年代国际关于甲壳动物免疫机制的资料，对甲壳动物中的酚氧化酶原激活系统的研究进展予以综合评价，目的在于为中国科技工作者防治虾蟹类疾病提供参考。现有的研究表明，甲壳动物中的酚氧化酶原激活系统可被微生物多糖激活，在激活过程中产生一系列活性物质，通过多种形式参与宿主防御反应。在甲壳动物中，与proPO系统有关的因子正在被逐步纯化出来。proPO可由内源蛋白酶转化成活性形式，存在调节因子调节proPO系统的释放与激活。与proPO系统有关的两种蛋白即76kD蛋白和BGBP－L直接参与细胞间信息传递。该系统在甲壳动物的识别、防卫及细胞间信息传递中发挥着重要作用。 |
| 关键词: 甲壳动物免疫 酚氧化酶原激活系统 蛋白酶抑制剂 细胞间信息传递 |
| DOI： |
| 分类号: |
| 基金项目:国家“八五”科技攻关资助资助项目，85-016-01-02号 |
附件 |
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| THE RESEARCH REVIEW OF PROPHENOLOXIDASE ACTIVATING SYSTEM IN CRUSTACEAN |
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MENG Fan-lun, ZHANG Yu-zhen, KONG Jian, MA Gui-rong
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State Key Laboratory of Microbiological Technology,Shandong University,Jinan,250100
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| Abstract: |
| Base on 1980’s and 1990’s data of the immunity system in crustaceans, the prophenoloxidase system is assessed in order to help the scientific researchers prevent and control crustacean diseases in china. Recent progress shows that the prophenoloxidase activating system in crustaceans can be activated by very few microbial polysaccharides. Several components are produced during the activation and involved in host defence. Some proteins associated with the prophenoloxidase system have been possible to be isolated and purified. It is clear that prophenoloxidase can be turned into its active form by an endogenous proteinase and regulatory factors are present which will regulate prophenoloxidase system activation. The 76KD protein and β-1, 3-glucan binding protein are involved in the communication between different blood cells. The prophenoloxidase system plays an important role in the host recognition, defence and cell-to-cell communication. |
| Key words: Crustacean immunity, Prophenoloxidase activating system, Proteinase inhibitors, Cell communication |
