| 摘要: |
| 观察孔石莼热水提取多糖和孔石莼乙醇提取物中的有效部位对小鼠实验性高脂血症水平的影响，发现孔石莼多糖250、500和1000mg／(kg?d)三个剂量组均具有降低小鼠血清总胆固醇(TC)、甘油三酯(TG)和低密度脂蛋白胆固醇(LDL-C)的作用，而高剂量组具有一定升高高密度脂蛋白胆固醇(HDL-C)的作用，其增加HDL-C／TC比值显著(P<0．05)。孔石莼乙醇提取物中的有效部位也具有降低血清TC、TG和LDL—C的作用，其降TC的作用稍次于孔石莼多糖，但其降低TG、升高HDL-C／TC比值的作用优于孔石莼多糖。 |
| 关键词: 孔石莼，多糖，乙醇提取物，高脂血症，调血脂 |
| DOI： |
| 分类号: |
| 基金项目:中国科学院方向性创新资助项目，KZCX3-SW-215号 |
附件 |
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| STUDY ON THE EFFECT OF THE ACTIVITIES OF ULVA PERTUSA ON RAT'S HYPERLIPAEMIA |
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WU Zhi-Jun, XU Zu-Hong, LI Zhi-En, NIU Xi-Zhen, ZHANG-Hong
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Institute of Oceanology, Chinese Academy of Science
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| Abstract: |
| To investigate the effect of the water-soluble polysaccharide and the effective section of the ethanol extract of Ulva pertusa against rat’s hyperlipaemia．The rat’s experimental model were made by hypercholesterol diet and were fed with three dose 1000mg/(kg?d)，500mg/(kg? d)，250mg/(kg? d)of polysaccharide and three dose 1.0g/(kg?d)，2.0 g/(kg?d)，3.0g/(kg? d)of the effective section of the ethanol extract of Ulva pertusa．The Chinese traditional medicine Xuezhikang was used as control group and the rat’s serum level of TC，TG，LDL-C，HDL-C were examined in the experiment．Three dose of the water-soluble polysaccharide and three dose of the effective section of the ethanol extract of Ulva pertusa had activities to lower the rat’s serum level of TC，TG，LDL-C and the high dose can increase the level of HDL-C/TC．The water-soluble polysaccharide and the effective section of the ethanol extract of Ulva pertusa have effects of cholesterol-lowering． |
| Key words: Ulva pertusa,Polysaccharide,Ethanol extract,Hype rlipaemia,Hypolipemic-effect |
