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MALDI-TOF质谱技术研究胰岛素海藻酸钠纳米粒特性
曾新华¹, 谢麟¹, 卓慧钦¹, 黄河宁², 林庆梅¹, 易瑞灶³, 黄河清¹
1.厦门大学生命科学学院，福建省化学生物学重点实验室，环境科学研究中心;2.三明学院化学与生物工程系;3.国家海洋局第三海洋研究所

摘要:

从海洋生物中提取海藻酸纳和壳聚糖作为纳米粒的包被材料,并分别包装成人胰岛素纳米粒。选用基质辅助激光解吸离子化飞行时间(Matrix-assisted laser desorption ionization/time of flight, MALDI-TOF)质谱技术研究胰岛素海藻酸钠纳米粒包装、释放过程及在不同酸碱介质条件下的稳定性。

关键词: MALDI-TOF 质谱胰岛素纳米粒包装稳定性

DOI：

分类号:

基金项目:国家自然科学基金资助项目(0402760633);福建省自然科学基金资助项目(C0310006)

Studies on characteristics of sodium alginate nanoparticles of the insulin by MALDI-TOF mass spectrometry

Abstract:

Sodium alginate and chitosan extracted from the halobios were selected as packaging materials of nanoparticles of the human insulin nanoparticles, respectively. Matrix-assisted laser desorption ionization /time of flight (MALDI-TOF) mass spectrometry was used to study the processes of packaging and releasing of the insulin and its stability in the different basic and acidic mediums from the sodium alginate nanoparticles .

Key words: MALDI-TOF mass spectrometry insulin nanoparticle stability

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