| 摘要: |
| 以5mg/L恩诺沙星浸浴菲律宾蛤仔(Ruditapes philippinarum)24h, 取血液、鳃、内脏团、足、闭壳肌5种组织, 反相高效液相色谱法测定其中的药物浓度。结果表明, 恩诺沙星按一级动力学过程从体内消除, 在5种组织中消除速率快慢不一, 其在菲律宾蛤仔血液、鳃、内脏团、足、闭壳肌中的消除曲线方程分别为c=6.995e-0.0853t, c=2.7957e-0.1177t, c=1.539e-0.1013t, c=1.7015e-0.1535t, c=2.010e-0.1414t, 消除半衰期T1/2分别为6.284, 5.889, 6.483, 4.516, 3.679h。恩诺沙星在水产品中的最大残留限量为50μg /kg, 在本实验条件下, 建议临床休药期不小于2d。 |
| 关键词: 菲律宾蛤仔(Ruditapes philippinarum) 恩诺沙星 消除 |
| DOI： |
| 分类号: |
| 基金项目:国家科技攻关计划资助项目(2002BA906A39);山东省科技发展计划资助项目(2003-4-1) |
|
| Study on elimination of enrofloxacin in Ruditapes philippinarum |
|
|
| Abstract: |
| The present preclinical study was performed to investigate the execration of enrofloxacin(EF) in Ruditapes philippinarum after bath treatment of 5 mg/L for 24 h. Plasma and tissue concentrations of EF were determined by HPLC. The equations of elimination curve of enrofloxacin in plasma, gill, visceral mass, foot and adductor muscle were c=6.995e-0.085 3 t, c=2.795 7e-0.117 7 t, c=1.539e-0.101 3 t, c=1.701 5e-0.153 5 t, c=2.010e-0.141 4 t, respectively. The elimination of half-lives(T1/2) was 6.284,5.889, 6.483, 4.516, 3.679 h, respectively. |
| Key words: Ruditapes philippinarum enrofloxacin elimination |
