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麻痹性贝毒对肝脏和肾脏氧化损伤的影响
陈 雪1,2, 程金平1, 张鉴达1, 宋玉玲1, 王文华1, 于金莲2
1.上海交通大学环境科学与工程学院;2.上海师范大学生命与环境科学学院
摘要:
为了探讨麻痹性贝毒(PSP)对肝脏和肾脏损伤的机制, 采用膝沟藻毒素GTX-1, 4 对小鼠进行急性暴露, 剂量为1μg/kg, 时间分别为60、90、120min。结果发现, 与对照组相比, 肝脏染毒组中的还原型谷胱甘肽(GSH)含量没有显著变化; 在肾脏中, 60 min 时染毒组GSH 含量没有明显变化, 90、120 min时GSH 含量降低 ; 两器官中抗氧化酶(GSH-Px、SOD)活性与对照组相比均无显著变化(P>0.05)。从而推断, GSH 参与了PSP 对肾脏损害的毒性过程; 肾中GSH 含量有可能作为PSP 早期检测的敏感指标。
关键词:  麻痹性贝毒  氧化损伤  肝脏  肾脏
DOI：
分类号:
基金项目:上海科委科技攻关项目(08dz1206302)
Effects of PSP-induced oxidative stress in liver and kidney
Abstract:
Oxidative stress induced by paralytic shellfish poisoning (PSP) in liver and kidney was studied by comparing mice acutely exposed to GTX-1,4. The exposure dose was 1μg/kg with different durations of 60, 90 and 120 min. The results found that the contents of GSH in liver changed slightly; in kidney, the contents of GSH were significantly decreased at 90 and 120min. The activities of GSH-Px and SOD were changed slightly in both organs (P> 0.05). These data indicate that GSH is involved in kidney injury of PSP; GSH content in kidney may be a sensitive indicator for detecting PSP.
Key words:  paralytic shellfish poisoning (PSP)  oxidative stress  liver  kidney
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