| 摘要: |
| 氮杂螺环酸也称原多甲藻酸，是一种具有独特螺环结构的聚醚类毒素，其对水产品的食品安全和消费者健康威胁极大，因此被双壳软体生物毒素工作组列为常见贝类毒素之一。但迄今人们对有关氮杂螺环酸的致毒机理、分子靶点以及生物毒性等，尚缺乏深入的了解。为推进对该类毒素的研究，本文就氮杂螺环酸的来源、检测方法、毒性及致毒机理以及对贝类生物的影响等进行了综述，并提出了未来需重点关注和解决的问题。 |
| 关键词: 氮杂螺环酸 贝类毒素 综述 |
| DOI：10.11759/hykx20180313002 |
| 分类号:Q178.53 |
| 基金项目:国家自然科学基金项目（41576116，41776120） |
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| Advances in research on azaspiracids |
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LÜ Jin-jin, LI Hong-ye, LIU Jie-sheng, YANG Wei-dong
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Key Laboratory of Aquatic Eutrophication and Control of Harmful Algal Blooms of Guangdong Higher Education Institute, College of Life Science and Technology, Jinan University, Guangzhou 510632, China
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| Abstract: |
| Azaspiracids are a type of polyether marine algal toxins with a unique 6, 5, 6-trispiroacetal moiety. They can accumulate in edible shellfish and can cause severe foodborne gastrointestinal illnesses in humans. Therefore, the joint FAO/IOC/WHO workshop on biotoxins in bivalve molluscs held in Dublin listed them as one of the common shellfish toxins. However, their toxic mechanism and molecular target in humans remain unclear as does their effect on shellfish. Here, to provide information for further study on azaspiracids, we reviewed their source, detection method, accumulation in shellfish (especially in bivalve molluscs), toxicity in humans, and effect on the shellfish. We have highlighted some issues that must be addressed in future studies. |
| Key words: azaspiracids shellfish review |
