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| 具有抑制植物病原真菌活性的含氮、硫、磷壳聚糖衍生物的研究进展 |
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邢荣娥1,2,3, 秦玉坤1,2,3, 李克成1,2,3, 刘松1,2,3, 李鹏程1,2,3
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1.中国科学院海洋研究所 实验海洋生物学重点实验室, 山东 青岛 266071;2.青岛海洋科学与技术试点国家实验室 海洋药物与生物制品功能实验室, 山东 青岛 266237;3.中国科学院海洋大科学研究中心, 山东 青岛 266071
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| 摘要: |
| 海洋生物体内蕴含着天然活性物质，许多都具有杀菌、杀虫、抗逆、促生长等功能，已成为新农药创制的重要源泉，据此研制新型海洋生物源农药，是海洋生物产业中的一个新领域，也是新型生物农药研发的重要途径。以虾、蟹壳为原料制备的壳聚糖是一种碱性多糖，能够促进植物生长，提高植物抗病、抗逆能力，在农业上受到广泛关注。为提高壳聚糖的应用性，通过改性提高其抑菌性是一个研究热点。本文主要基于本实验室近20年来在壳聚糖衍生化及抑菌活性方面开展的工作，系统地阐述了提高壳聚糖抑菌活性的活性拼接改性策略，即通过在不同位点接枝含氮、含磷、含硫等抑菌活性基团以提高其抑菌活性，分析了其构效关系，为研制新型海洋生物农药提供了理论与技术支撑。 |
| 关键词: 壳聚糖衍生物 植物病原真菌 抑制活性 |
| DOI：10.11759/hykx20200117004 |
| 分类号:P745;O636.9 |
| 基金项目:国家重点研发计划（2018YFC0311305） |
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| Research progress of chitosan derivatives containing nitrogen, sulfur and phosphorus with inhibitory activity on plant pathogenic fungi |
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XING Rong-e1,2,3, QIN Yu-kun1,2,3, LI Ke-cheng1,2,3, LIU Song1,2,3, LI Peng-cheng1,2,3
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1.Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Qingdao 266071, China;2.Laboratory for Marine Drugs and Bioproducts, Pilot National Laboratory for Marine Science and Technology(Qingdao), Qingdao 266237, China;3.Center for Ocean Mega-Science, Chinese Academy of Sciences, Qingdao 266071, China
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| Abstract: |
| Marine organisms contain natural active substances, many of which have sterilization functions, insecticides, stress resistance, growth promotion, etc. have become an important source of new pesticide production. The development of new marine biological pesticides is therefore a new field in the marine biological industry and an important way of research and development of new biological pesticide. Chitosan made from shrimp and crab shell is a kind of alkaline polysaccharide that can foster plant growth, enhance plant resistance to disease and stress, and is widely involved in agriculture. It is a research hotspot to improve its bactericidal properties by alteration, to improve the application of chitosan. In this paper, based on the work of our laboratory over the last 20 years in the field of chitosan derivatization and antibacterial activity, the active splicing modification strategy is systematically defined to improve the bactericidal activity of chitosan, i.e., to improve the bacteriostatic activity of chitosan by grafting the bacteriostatic active groups such as nitrogen, phosphorus, sulfur, and metal complexes at different sites and to discuss and summarize the structure-activity relationship. It provides theoretical and technical support for the development of new marine biopesticides. |
| Key words: chitosan derivatives plant pathogenic fungi inhibitory activity |