| 摘要: |
| 静电纺丝是一种简易高效的制备连续纳米级至微米级纤维的技术。壳聚糖是自然界中唯一存在的碱性阳离子多糖,静电纺丝法制备的壳聚糖基纳米纤维具有比表面积大、孔隙率高、给药能力强、生物相容性好、生物降解性好、止血、抗菌、促愈合等优点,在组织工程领域具有广阔的应用前景。本文综述了壳聚糖基静电纺丝纳米纤维的制备及其在骨、皮肤、血管和神经组织工程领域的研究进展,对其在组织工程领域未来的发展方向进行展望,以期为后续研究提供理论参考。 |
| 关键词: 壳聚糖 静电纺丝 纳米纤维 组织工程 |
| DOI：10.11759/hykx20211031002 |
| 分类号:O636.1;R318;TQ340.64 |
| 基金项目:国家重点研发计划-基于壳聚糖的大创伤急救修复医用材料研究开发(2018YFC0311102) |
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| Preparation of chitosan-based electrospinning nanofibers and their application in tissue engineering |
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WHANG Yunpei, LIU Chenguang
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College of Marine Life Sciences, Ocean University of China, Qingdao 266003, China
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| Abstract: |
| Electrospinning is a simple and efficient technology used to prepare continuous nano or microfibers. Chitosan is the only natural alkaline cationic polysaccharide. Chitosan-based nanofibers prepared through electrospinning have the advantages of large specific surface area, high porosity, strong drug delivery ability, good biocompatibility, good biodegradability, hemostasis, antibacterial ability, and healing promotion ability. Hence, they have broad application prospects in the field of tissue engineering. The preparation of chitosan-based electrospinning nanofibers and research advances of such nanofibers in bone, skin, blood vessels, and nerve tissue engineering have been reviewed. Finally, we present the future development direction of chitosan-based electrospinning nanofibers in tissue engineering and expect to provide a theoretical reference for future research. |
| Key words: chitosan electrospinning nanofibers tissue engineering |
