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鱼类生长激素的分子生物学和应用研究的进展
徐斌^1,2, 李德尚^1,2, 张培军³
1.青岛海洋大学国家教委水产养殖开放研究实验室青岛;266003;3.中国科学院海洋研究所青岛 266071

摘要:

依据1985－1995年国际有关资料对鱼类生长激素的分子生物学及其应用研究的最新成果与进展进行综合评述。研究表明，已完成鳗鲡等9种鱼类生长激素的氨基酸组成与全序列分析及大麻哈鱼等20种鱼类的生长激素基因的分离与克隆，有些已在工程菌或动物细胞中高效表达；鱼类生长激素基因的调控机制与生长激素的活性部位研究正在深入进行；将外源的生长激素引入鱼体或将外源的生长激素基因导入受体鱼，以期促进生长、增加抗性，是生长激素应用于水产养殖研究的主要方向。

关键词: 鱼类生长激素分子生物学基因应用进展

DOI：

分类号:

基金项目:国家自然科学基金资助项目，39470553号

ADVANCES IN STUDIES ON MOLECULAR BIOLOGY AND APPLICATIONS OF FISH GROWTH HORMONE

Xu Bin,Li Deshang,Zhang Peijun

1.Open Laboratory on Aquacultural Research of the State Educational Committee of China,Ocean University of Qingdao,Qingdao 266003;2.Institute of Oceanology , Chinese Academy of Sciences, Qingdao 266071

Abstract:

Based on 1985 - l995 published data, this paper reviews the advances and latest results in studies on molecular biology and applications of fish growth hormone (GH). Recently, the amino acid compositions and complete amino acid sequences of 9 fish GHs, such as those of eel, etc., were determined. About 20 fish GH genes, including chum salmon, etc., have been isolated and cloned, and some have been expressed in engineering bacterium, yeast and animal cells. Studies on the regulatory mechanism (s) of fish GH genes and bioactive domains in fish GH are being intensively carried out. In order to promote growth and increase disease resistance, the exogenous GH and GH genes are delivered and transferred to farmed fish.

Key words: Fish, Growth hormone (GH), Molecular biology, Gene, Application, Advances

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