| 引用本文: | 曾新华,谢 麟,卓慧钦,黄河宁,林庆梅,易瑞灶,黄河清.MALDI-TOF质谱技术研究胰岛素海藻酸钠纳米粒特性[J].海洋科学,2006,30(1):73-77. |
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| 摘要: |
| 从海洋生物中提取海藻酸纳和壳聚糖作为纳米粒的包被材料,并 分别包装成人胰岛素纳米粒。选用基质辅助激光解吸离子化飞行时间(Matrix-assisted laser desorption ionization/time of flight, MALDI-TOF)质谱技术研究胰岛素海藻酸钠纳米 粒包装、释放过程及在不同酸碱介质条件下的稳定性。 |
| 关键词: MALDI-TOF 质谱 胰岛素 纳米粒包装 稳定性 |
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| 基金项目:国家自然科学基金资助项目(0402760633);福建省自然科学基金资助项目(C0310006) |
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| Studies on characteristics of sodium alginate nanoparticles of the insulin by MALDI-TOF mass spectrometry |
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| Abstract: |
| Sodium alginate and chitosan extracted from the halobios were selected as packaging materials of nanoparticles of the human insulin nanoparticles, respectively. Matrix-assisted laser desorption ionization /time of flight (MALDI-TOF) mass spectrometry was used to study the processes of packaging and releasing of the insulin and its stability in the different basic and acidic mediums from the sodium alginate nanoparticles . |
| Key words: MALDI-TOF mass spectrometry insulin nanoparticle stability |