| 摘要: |
| 哺乳动物类白蛋白家族成员包括白蛋白（albumin，ALB）、维生素D结合蛋白（vitamin D binding protein，DBP）、甲胎蛋白（alpha-fetoprotein，AFP）和alpha-白蛋白（afamin，AFM）以及甲胎蛋白相关蛋白（alpha-fetoprotein related protein，ARG），以含有白蛋白结构域为主要特征。前4种蛋白都存在于血清中，参与脂肪酸或激素等的转运，后一种可能存在于细胞中。文中就类白蛋白家族的主要结构特点、相关功能及进化图式等进行阐述，为后续探索该家族成员的演化和应用提供了参考。 |
| 关键词: 白蛋白 结构 生理功能 进化 |
| DOI：10.11759/hykx20210317001 |
| 分类号:Q512+.1 |
| 基金项目:国家自然科学基金项目（31970429）；山东省自然科学基金（ZR2020MC050） |
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| The structure, function and evolution of mammalian albumin multigene family |
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YUAN Jian-rui, FENG Ying, ZHANG Xiao-hui, JI Guang-dong
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Ocean University of China, College of Marine Life Sciences, Institute of Evolution & Marine Biodiversity, Qingdao 266003, China
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| Abstract: |
| Albumin multigene family in mammals consists of albumin (ALB), Vitamin D binding protein (DBP), alpha-Fetoprotein (AFP), alpha-albumin (AFM) and alpha-fetoprotein related protein (ARG), with the main characteristics of containing albumin domain. The former four proteins are present in the serum and are involved in transporting fatty acids or hormones, while ARG is probably localized in cell. This review will focus on the main structural characteristics, related functions and evolution of albumin family. |
| Key words: albumin structure physiological function evolution |
