引用本文:	王蕾,吕康宁,李文军,王凯,姜晓锐,秦松.两种不同海洋生物材料对大鼠急性创面修复效果的研究[J].海洋科学,2023,47(10):87-93.

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两种不同海洋生物材料对大鼠急性创面修复效果的研究
王蕾^1,2, 吕康宁¹, 李文军¹, 王凯³, 姜晓锐³, 秦松¹
1.中国科学院烟台海岸带研究所, 山东烟台 264003;2.中国科学院大学, 北京 100049;3.烟台毓璜顶医院, 山东烟台 264001

摘要:

为研究来源于海洋的鱼类胶原蛋白和海藻酸盐对创面的修复效果,建立大鼠皮肤急性创面模型,对两种材料的功效进行探索。研究采用临床常用创面敷料使用方法,将两种材料植入创面处,采用细胞生物学、病理学等方法进行观察评价。结果显示,鱼胶原蛋白和海藻酸盐均具有良好的生物相容性和诱导创面修复能力,但在诱导血管长入、材料降解融合以及整体创面修复状态等方面,鱼类胶原蛋白要优于海藻酸盐。结果证明,两种不同的海洋生物材料均可以创造良好的伤口愈合环境,有效促进创面的修复。

关键词: 创面修复海藻酸盐胶原蛋白诱导

DOI：10.11759/hykx20220120004

分类号:Q819

基金项目:山东省重点研发计划(重大科技创新工程)(2019JZZY011103)

Effect of two different marine biomaterials on acute wound repair in rats

WANG Lei^1,2, LV Kang-ning¹, LI Wen-jun¹, WANG Kai³, JIANG Xiao-rui³, QIN Song¹

1.Yantai Institute of Coastal Zone Research, Yantai 264003, China;2.University of Chinese Academy of Sciences, Beijing 100049, China;3.Yantai Yuhuangding Hospital, Yantai 264001, China

Abstract:

To investigate the wound healing effects of marine fish collagen and alginate, we established rat skin acute wound models and evaluated the efficacy of these two materials. We employed commonly used clinical wound dressing methods by implanting both materials into the wounds and observed and evaluated the outcomes using cell biology and pathology techniques. The results indicated that both fish collagen and alginate exhibited excellent biocompatibility and the ability to stimulate wound repair. However, fish collagen outperformed alginate in terms of promoting blood vessel ingrowth, material degradation and fusion, and overall wound healing. These findings demonstrate that both marine biomaterials create a conducive environment for wound healing and effectively facilitate the wound repair process.

Key words: wound repair alginate collagen induction