| 摘要: |
| 海洋双壳贝类在全球渔业与水产养殖中具有显著的经济和生态价值。Argopecten属海湾扇贝(A. irradians)(<14个月)和紫扇贝(A. purpuratus)(7~10 a)不完全生殖隔离, 但在长期适应不同环境的进化过程中, 各自基因组的遗传变异导致了二者不同的寿命周期, 为研究寿命演化机制提供了独特材料。IIS通路(胰岛素/胰岛素样生长因子信号通路)是机体从生长、代谢到生殖和寿命等生命过程的关键信号传导途径, 是第一个被发现且得到广泛验证的衰老调控信号通路。本文从遗传和环境角度综述了IIS通路在两种Argopecten属扇贝寿命决定中的潜在机制。遗传变异导致IIS通路核心基因不同的蛋白酶活性及磷酸化水平, 而环境胁迫下IIS通路调控、抗氧化和DNA修复、代谢调节等方面的差异可能是导致Argopecten属扇贝寿命差异的重要原因。 |
| 关键词: Argopecten属扇贝 寿命 IIS通路 营养限制 电离辐射 基因组稳定 |
| DOI：10.11759/hykx20241030002 |
| 分类号:P735 |
| 基金项目:国家自然科学基金资助项目(42276147, 31972791); 山东省重点研发计划项目(2023ZGCQY006); 山东省贝类产业技术体系遗传育种岗位专家项目(SDAIT-14) |
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| Regulatory mechanism of lifespan of bay scallops and peruvian scallops of Argopecten |
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ZHANG Zebin1, JIANG Nan1, TANG Yongzheng1, WANG Chunde2, LU Xia1
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1.School of Ocean, Yantai University, Yantai 264005, China;2.Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China
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| Abstract: |
| Marine bivalves hold significant economic, ecological, and sustainable developmental value in global fisheries and aquaculture. American scholars have reported that marine bivalves are ideal models for analyzing the regulatory mechanisms of natural aging and longevity. Bay scallops (Argopecten irradians) (<14 months) and Peruvian scallops (A. purpuratus) (7-10 a) are not completely reproductively isolated; however, the genetic variations in their genomes resulting from long-term adaptation to different environments have led to distinct lifespans, providing unique materials for investigating lifespan evolution mechanisms. The insulin/insulin-like growth factor signaling (IIS) pathway is a key pathway involved in various life processes, including growth, metabolism, reproduction, and lifespan. It is the first aging regulatory signaling pathway discovered and widely validated. This study reviews the potential mechanisms influencing lifespan determination through the IIS pathway in the two species of Argopecten from genetic and environmental perspectives. Genetic variation results in differences in protease activity and phosphorylation levels of core genes within the IIS pathway. Under environmental stress, variations in IIS pathway regulation, antioxidant and DNA repair responses, and metabolic regulation may contribute to the differences in lifespan among Argopecten scallops. This review provides new insights into evaluating lifespan evolution mechanisms in marine bivalves, further enhancing the theoretical understanding of aging and longevity mechanisms. Additionally, it offers theoretical foundations and biological markers for breeding long-lived, larger scallops. |
| Key words: Argopecten scallops lifespan IIS pathway nutritional restriction ionizing radiation genomic stability |
