| 摘要: |
| BDDPM是一种从海洋松节藻中分离出来的全新结构的溴酚类化合物, 前期研究表明BDDPM具有良好的PTP1B蛋白酶活抑制能力。在本文中利用HepG2细胞和C2C12细胞, 研究BDDPM 对肝细胞糖原合成能力的影响及对胰岛素抵抗的作用。结果表明, 1 μmol/L BDDPM可以在细胞水平显著激活胰岛素信号通路, 提高肝糖原的合成, 缓解棕榈酸诱导的胰岛素抵抗, 初步具有开发成为新型抗糖尿病海洋药物的潜力。 |
| 关键词: 松节藻 BDDPM T2DM 糖原合成 胰岛素抵抗 |
| DOI：10.11759/hykx20160413001 |
| 分类号: |
| 基金项目:国家自然科学基金面上项目(41276167); 山东省重点研发计划(2015GGF01039); 青岛市基础研究计划项目(No.14-2-4-35-jch);国家高层次人才特支计划“万人计划”; 国家海洋实验室“鳌山人才计划” |
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| A study on hepatic glycogen synthesis and insulin resistance of marine derived bromophenol BDDPM |
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LUO Jiao,XU Qi,WANG Li-jun,JIANG Bo,SHI Da-yong
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| Abstract: |
| Bis (2, 3-dibromo-4, 5-dihydroxy-phenyl)-methane (BDDPM) is a bromophenol compound with a new structure extracted from the marine red algae Rhodomela confervoides. A previous study showed that BDDPM could significantly inhibit PTP1B activity in vitro. In this research, we studied the effect of BDDPM on hepatic glycogen synthesis ability and insulin resistance in HepG2 and C2C12 cells. The results reveal that 1-μM BDDPM can significantly activate insulin signaling, enhance hepatic glycogen synthesis, and alleviate PA-induced insulin resistance. As such, BDDPM has the potential to be developed as an anti-diabetic agent. |
| Key words: Rhodomela confervoides BDDPM T2DM glycogen synthesis insulin resistance |
