| 摘要: |
| 藻蓝蛋白是蓝藻中的一种主要活性成分，研究发现藻蓝蛋白有多种功能，可以清除氧自由基，且含有多种氨基酸能够抗衰老、抗过敏，为对藻蓝蛋白用于化妆品行业的可行性进行探究，本文采用新西兰白兔作为动物模型，通过光毒性、急性经皮毒性以及皮肤变态反应实验，验证其对皮肤的毒性作用。结果显示，藻蓝蛋白对白兔没有明显的毒性作用，也未引起皮肤过敏反应，为其在美容化妆方面的应用提供了参考。 |
| 关键词: 藻蓝蛋白 抗氧化 光毒性实验 急性经皮毒性实验 皮肤变态反应试验 化妆品 |
| DOI：10.12036/hykxjk20170317001 |
| 分类号:TQ041 |
| 基金项目:海洋公益性行业科研专项（20120527）；中国科学院战略性先导科技专项（XDA1102040300）；国家自然科学基金项目（41176144，41376139）；国家科技支撑计划（2013BAB01B01）；烟台市科技计划（2016JHZB007）资助。 |
|
| Experimental Study of Dermal Toxicity of Phycocyanin |
|
LIU Qi1, WU Zhong-Ying2, JIAO Xu-Dong1, LIU Bing1, LI Wen-Jun1
|
|
1.Key Laboratory of Coastal Biology and Biological Resource Industry, Yantai Institute of Coastal Zone Research, Chinese Academy of Sciences, Yantai 264003, China;2.Shandong Qunying Medicine Co. Ltd., Yantai 264005, China
|
| Abstract: |
| Phycocyanin is one of the main active compounds present in cyanobacteria. It has multiple functions, such as scavenging oxygen free radicals, and it has anti-aging and anti-allergy properties that are manifested in combination with a variety of amino acids. In order to study the feasibility of using phycocyanin in the cosmetics industry, we consider the New Zealand rabbits as the model animal and conduct experiments such as light toxicity, acute dermal toxicity, and skin allergy tests to verify its toxic effects on the skin of the rabbit. The results show no obvious toxicity and no allergic reactions to the skin of the rabbits. These results provide a reference for the application of phycocyanin in the fields of cosmetology and makeup. |
| Key words: phycocyanin antioxidant light toxicity acute percutaneous toxicity skin allergy cosmetics |
