| 摘要: |
| 1997年9月自青岛太平角潮间带采集角叉菜，采用不同的提取和降解方法，得到不同分子量的角叉菜多糖，利用其进行对小鼠肝癌H-22的抗肿瘤实验。结果表明，用蒸馏水直接提取并用H2O2降解角叉菜多糖，所得样品的特性粘度与所加H2O2的量呈近似指数关系;分子量是影响角叉菜多糖抗肿瘤作用的重要因素。对于肝癌H-22而言，角叉菜多糖分子量适当减小可使抑瘤率升高，但分子量太小又会使抑瘤率迅速降低，具有适中分子量的角叉菜多糖能保持高的抑瘤率。 |
| 关键词: 角叉菜多糖 降解 抗肿瘤活性 |
| DOI：10.11693/hyhz200006011011 |
| 分类号: |
| 基金项目:国家自然科学基金资助项目，39870067号 |
|
| ANTITUMOR ACTIVITY OF DEGRADED CHONDRUS OCELLATUS POLYSACCHARIDE |
|
SHI Ran-xin, XU Zu-hong, LI Zhi-en
|
|
Institute of Oceanology,The Chinese Academy of Sciences,Qingdao,266071
|
| Abstract: |
| Chondrus ocellatus polysaccharide is a polysaccharide of high molecular weight in the cell wall of C. ocellatus. It can be applied in industry and pharmacology, producing food additives, thickening agent, emulsifying agent and drug’s excipient, release delaying agent, and is also used as drug to cure ulcer, dysentery and enteritis. Its effects of antivirus and treating cardiovascular diseases have been reported.
Recent discovery of the antitumor effect of C. ocellatus polysaccharide led us to further study its antitumor activity. Polysaccharides with different molecular weight were obtained by depolymerization. Extracts’ intrinsic viscosity presented an index decrease with H2O2 added, the logarithm of extract’s intrinsic viscosity presented a linear decrease with H2O2 added. In vivo antitumor experiments showed that molecular weight of C. ocellatus polysaccharide were important to its antitumor effects. As to hepatitis virus tumor (H-22), tumor inhibit rate would be higher if the molecular weight was reduced to certain limit, but it would be lower if the molecular weight was reduced too much. |
| Key words: Chondrus ocellatus, Degradation, Antitumor activity |
