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| 引用本文: | 张 一,李晓明,尚 卓,李春顺,王斌贵.红树林植物木榄根际土壤真菌Penicillium sp. MA-37 的化学成分研究[J].海洋科学,2013,37(2):7-11. |
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| 红树林植物木榄根际土壤真菌Penicillium sp. MA-37 的化学成分研究 |
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张 一1,2, 李晓明1, 尚 卓1, 李春顺1, 王斌贵1
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1.中国科学院 海洋研究所 实验海洋生物学重点实验室;2.中国科学院 研究生院
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| 摘要: |
| 对采自海南文昌红树林根际土壤样品中分离到的真菌Penicillium sp. MA-37 的次生代谢产物的化学成分进行了研究。利用硅胶柱层析、葡聚糖凝胶Sephadex LH-20 柱层析、制备薄层层析以及重结晶等分离方法并通过现代波谱技术共分离、鉴定了8 个天然产物, 分别为: 氮-(2-甲氧基-4-羟基苯)-丙酰胺酸(1), 氮-(2,4-二甲氧基苯)-丙酰胺酸(2), 氮-(2,4-二甲氧基苯)-丙酰胺酸甲酯(3), (22E,24R)-麦角甾-5,7,22-三烯-3β-醇(4), (22E,24R)-麦角甾-4,6,8(14),22-四烯-3-酮(5), (22E,24R)-5α,8α-环二氧麦角甾-6,22-双烯-3β-醇(6), asperamide B (7), cis-4-hydroxy-6-deoxyscytalone (8); 其中化合物1 为新化合物, 化合物2 和3 为新天然产物。 |
| 关键词: 红树林 根际土壤 新化合物 次生代谢产物 |
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| 基金项目:国家自然科学基金(30910103914)项目; 科技部“973 计划”项目(2010CB833802) |
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| Chemical constituents of Penicillium sp. MA-37, a fungus derived from rhizospheres of mangrove plant Bruguiera gymnorrhiza |
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| Abstract: |
| From the fermentation culture of strain Penicillium sp. MA-37 derived from mangrove rhizosphere, eight compounds were isolated by separation techniques including column chromatography with silica gel and Sephadex LH-20, preparative TLC and re-crystallization. Structures of all purified compounds were elucidated by analysis of their spectroscopic data to be N-(2-methoxy-4-hydroxyphenyl)-malonamic acid (1), N-(2,4-dimethoxyphenyl)-malonamic acid (2), N-(2,4-dimethoxyphenyl)-malonamic acid methyl ester (3), (22E,24R)-ergosta-5,7,22-trien-3β-ol (4), (22E,24R)-Ergosta-4,6,8(14),22-tetraen-3-one (5), (22E,24R)-5α,8α-epidioxyergosta-6,22-dien-3β-ol (6), asperamide B (7), cis-4-hydroxy-6-deoxyscytalone (8). Compound 1 was a new compound, while compounds 2 and 3 were reported as natural products for the first time. |
| Key words: Mangrove rhizosphere novel compound secondary metabolites |
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