| 引用本文: | 刘小卓,张晓明,董 波.海洋动物microRNAs研究进展与展望[J].海洋科学,2018,42(3):157-168. |
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| 海洋动物microRNAs研究进展与展望 |
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刘小卓1, 张晓明1,2, 董 波1,2
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1.中国海洋大学 海洋生命学院;2.青岛海洋科学与技术国家实验室 海洋生物学与生物技术功能实验室
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| 摘要: |
| MicroRNAs(miRNAs)是一类小分子非编码RNA, 通过特异性结合靶基因, 对靶基因转录后表达进行调控。miRNAs参与众多生物学过程并发挥关键调控角色。作者介绍了miRNAs生物合成和作用机制, 回顾了近年来海洋动物miRNA研究取得的进展, 并阐述了目前已知的miRNA对海洋动物重要生理过程的调控过程和机制, 旨在为今后更深入地研究海洋动物miRNA功能提供参考。 |
| 关键词: microRNA 海洋动物 生长和发育 免疫 附着变态 |
| DOI：10.11759/hykx 20171211001 |
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| 基金项目:国家自然科学基金项目(41706153); 山东省泰山学者建设工程专项经费资助(201502035) |
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| Progress and perspective of microRNA research in marine animals |
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LIU Xiao-zhuo,ZHANG Xiao-ming,DONG Bo
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| Abstract: |
| MicroRNAs (miRNAs) are small noncoding RNAs that modulate the expression of diverse targeted mRNAs at the posttranscriptional level. They are also known to be involved in numerous biological processes. Although a large number of miRNAs have been identified in marine animals, only a few investigations have been conducted on their functional mechanisms. In this review, we first summarize the biogenesis mechanisms and the advances in miRNA identification in marine animals. We then focus on the progress made in the research on miRNA functions in some specific physiological processes of marine animals, such as osmotic regulation, immune, and metamorphosis. Finally, we outline a prospective of the research on marine animal miRNAs. |
| Key words: microRNAs marine animals osmotic regulation immune metamorphosis |
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